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|Title:||Hemophagocytic Lymphohistiocytosis Due to Rickettsia Japonica in a 3-Month-old Infant|
|Authors:||Shoichiro Otsuki;Shotaro Iwamoto;Eiichi Azuma;Yuji Nashida;Shigehiro Akachi|
|Abstract:||Rickettsia japonica, transmitted to human by various tick species, is the causative agents for Japanese spotted fever (JSF) clinically manifested with high fever, rash, and eschar.1–3 Approximately 30 to 40 cases of JSF have been reported annually in East Asia, especially Japan.2 Most patients with JSF have mild symptoms and improve after administration of appropriate antibiotics. However, severe cases with fatal complications, including encephalitis, multiorgan failure, or acute respiratory distress syndrome, have been reported due to hypercytokinemia associated with the delay in the initiation of adequate treatment.3 Here, we present the first reported case of R. japonica infectioninduced hemophagocytic lymphohistiocytosis (HLH).|
|Appears in Collections:||Journal of pediatric hematology oncology 2015|
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