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PreviewIssue DateTitleContributor(s)
2016 JMC Volume 59 Issue 10 May (17).pdf.jpg2016Identi fi cation and Development of 2,3- Dihydropyrrolo[1,2 ‑ a ]quinazolin-5(1 H ) ‑ one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting ComplexSutherell, Charlotte L.
2016 JMC Volume 59 Issue 8 April (28).pdf.jpg2016Discovery of N ‑ (3-((1-Isonicotinoylpiperidin-4-yl)oxy)-4- methylphenyl)-3-(tri fl uoromethyl)benzamide (CHMFL-KIT-110) as a Selective, Potent, and Orally Available Type II c ‑ KIT Kinase Inhibitor for Gastrointestinal Stromal Tumors (GISTs)Wang, Qiang
2016 JMC Volume 59 Issue 1 January (16).pdf.jpg2016Important Hydrogen Bond Networks in Indoleamine 2,3- Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1Peng, Yi-hui; Ueng, Shau-hua; Tseng, Chen-tso; Hung, Ming-shiu; Song, Jen-shin; Wu, Jian-sung; Liao, Fang-yu; Fan, Yu-shiou; Wu, Mine-hsine; Hsiao, Wen-chi; Hsueh, Ching-cheng; Lin, Shu-yu; Cheng, Chia-yi; Tu, Chih-hsiang; Lee, Lung-chun; Cheng, Ming-fu; Shia, Kak-shan; S
2016 JMC Volume 59 Issue 4 February (28).pdf.jpg2016Identi fi cation of a Benzoisoxazoloazepine Inhibitor (CPI-0610) of the Bromodomain and Extra-Terminal (BET) Family as a Candidate for Human Clinical TrialsAlbrecht, Brian K; Gehling, Victor S; Hewitt, Michael C; Vaswani, Rishi G; Co, Alexandre; Leblanc, Yves; Nasveschuk, Christopher G; Bellon, Steve; Bergeron, Louise; Campbell, Robert; Cantone, Nico; Cooper, Michael R; Cummings, Richard T; Jayaram, Hariharan; Joshi, Shiv
2016 JMC Volume 59 Issue 5 March (12).pdf.jpg2016Identi fi cation of Novel GPR55 Modulators Using Cell-Impedance- Based Label-Free TechnologyMorales, Paula; Whyte, Lauren S; Chicharro, Roberto; Goya, Pilar; Irving, Andrew J; Ferna, Javier; Ross, Ruth A; Jagerovic, Nadine
2016 JMC Volume 59 Issue 6 March (5).pdf.jpg2016How Beyond Rule of 5 Drugs and Clinical Candidates Bind to Their TargetsDoak, Bradley C; Zheng, Jie; Dobritzsch, Doreen; Kihlberg, Jan
2016 JMC Volume 59 Issue 4 February (5).pdf.jpg2016Structure-Guided Design of IACS-9571, a Selective High-A ffi nity Dual TRIM24-BRPF1 Bromodomain InhibitorPalmer, Wylie S; Poncet-montange, Guillaume; Liu, Gang; Petrocchi, Alessia; Reyna, Naphtali; Subramanian, Govindan; Thero, Jay; Yau, Anne; Kost-alimova, Maria; Bardenhagen, Jennifer P; Leo, Elisabetta; Shepard, Hannah E; Tieu, Trang N; Shi, Xi; Zhan, Yanai; Zhao, Shupin
2016 JMC Volume 59 Issue 6 March (8).pdf.jpg2016Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of SchistosomiasisHeimburg, Tino; Chakrabarti, Alokta; Lancelot, Julien; Marek, Martin; Melesina, Jelena; Hauser, Alexander-thomas; Shaik, Tajith B; Duclaud, Sylvie; Robaa, Dina; Erdmann, Frank; Schmidt, Matthias; Romier, Christophe; Pierce, Raymond J; Jung, Manfred; Sippl, Wolfgang
2016 JMC Volume 59 Issue 3 February (32).pdf.jpg2016Structure − Activity Relationship Study of Rakicidins: Overcoming Chronic Myeloid Leukemia Resistance to Imatinib with 4 ‑ Methylester-Rakicidin ASang, Feng; Ding, Yahui; Wang, Jinghan; Sun, Bingxia; Sun, Jianlei; Geng, Yan; Zhang, Zhang; Ding, Ke; Wu, Ling-ling; Liu, Jian-wei; Bai, Cuigai; Yang, Guang; Zhang, Quan; Li, Lu-yuan; Chen, Yue
2016 JMC Volume 59 Issue 2 January (19).pdf.jpg2016Subhas S. Karki, † , # Umashankar Das, * , † Naoki Umemura, ‡ Hiroshi Sakagami, ‡ Shoko Iwamoto, ‡ Masami Kawase, § Jan Balzarini, ∥ Erik De Clercq, ∥ Stephen G. Dimmock, ⊥ and Jonathan R. Dimmock * , † †Karki, Subhas S; Das, Umashankar; Umemura, Naoki; Sakagami, Hiroshi; Iwamoto, Shoko; Kawase, Masami; Balzarini, Jan; Clercq, Erik De; Dimmock, Stephen G; Dimmock, Jonathan R
2016 JMC Volume 59 Issue 4 February (26).pdf.jpg2016Structure-Based Identi fi cation of Inhibitory Fragments Targeting the p300/CBP-Associated Factor BromodomainBromodomain, Cbp-associated Factor; Chaikuad, Apirat; Brennan, Paul E; Temperini, Claudia; Fedorov, Oleg; Hollander, Johan; Nachane, Ruta; Abell, Chris; Mu, Susanne; Siegal, Gregg; Knapp, Stefan
2016 JMC Volume 59 Issue 1 January (30).pdf.jpg2016Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Di ff erent Binding Modes at AMPA ReceptorsSzymanska, Ewa; Frydenvang, Karla; Pickering, Darryl S; Krintel, Christian; Nielsen, Birgitte; Kooshki, Ayesheh; Zachariassen, Linda G; Olsen, Lars; Kastrup, Jette S; Johansen, Tommy N
2016 JMC Volume 59 Issue 2 January (18).pdf.jpg2016Structure-Based Discovery of Novel and Selective 5 ‑ Hydroxytryptamine 2B Receptor Antagonists for the Treatment of Irritable Bowel SyndromeZhou, Yu; Lin, Xingyu; Huang, Xi-ping; Wu, Kaichun; Huang, Niu
2016 JMC Volume 59 Issue 7 April (1).pdf.jpg2016Anti-HIV Drug Discovery and Development : Current Innovations and Future TrendsZhan, Peng; Pannecouque, Christophe; Clercq, Erik De; Liu, Xinyong
2016 JMC Volume 59 Issue 1 January (3).pdf.jpg2016Structural Insights into the Competitive Binding of Diclofenac and Naproxen by Equine Serum AlbuminSekula, Bartosz; Bujacz, Anna
2016 JMC Volume 59 Issue 6 March (23).pdf.jpg2016Development and Pharmacological Characterization of Selective Blockers of 2 ‑ Arachidonoyl Glycerol Degradation with E ffi cacy in Rodent Models of Multiple Sclerosis and PainBrindisi, Margherita; Maramai, Samuele; Gemma, Sandra; Brogi, Simone; Grillo, Alessandro; Di, Lorenzo; Mannelli, Cesare; Gabellieri, Emanuele; Lamponi, Stefania; Saponara, Simona; Gorelli, Beatrice; Tedesco, Daniele; Bon, Tommaso; Landry, Christophe; Jung, Kwang-mook; A
2016 JMC Volume 59 Issue 7 April (35).pdf.jpg2016Design, Synthesis, and Biological Evaluation of Imidazo[1,5 ‑ a ]quinoline as Highly Potent Ligands of Central Benzodiazepine ReceptorsCappelli, Andrea; Anzini, Maurizio; Castriconi, Federica; Grisci, Giorgio; Paolino, Marco; Braile, Carlo; Valenti, Salvatore; Giuliani, Germano; Vomero, Salvatore; Capua, Angela Di; Betti, Laura; Giannaccini, Gino; Lucacchini, Antonio; Ghelardini, Carla; Di, Lorenzo; Ma
2016 JMC Volume 59 Issue 5 March (24).pdf.jpg2016Designed Glycopeptidomimetics Disrupt Protein − Protein Interactions Mediating Amyloid β ‑ Peptide Aggregation and Restore Neuroblastoma Cell ViabilityKa, Julia; Brinet, Dimitri; Soulier, Jean-louis; Correia, Isabelle; Tonali, Nicolo; Fera, Katia Fabiana; Iacone, Yasmine; Ho, R F; Khemte, Lucie; Crousse, Benoit; Taylor, Mark; Allsop, David; Taverna, Myriam; Lequin, Olivier; Ongeri, Sandrine
2016 JMC Volume 59 Issue 5 March (14).pdf.jpg2016A Parallel Synthesis Approach to the Identi fi cation of Novel Diheteroarylamide-Based Compounds Blocking HIV Replication: Potential Inhibitors of HIV ‑ 1 Pre-mRNA Alternative SplicingCheung, Peter K; Horhant, David; Bandy, Laura E; Zamiri, Maryam; Rabea, Safwat M; Karagiosov, Stoyan K; Matloobi, Mitra; Mcarthur, Steven; Harrigan, P Richard; Chabot, Benoit; Grierson, David S
2016 JMC Volume 59 Issue 1 January (9).pdf.jpg2016Discovery and Characterization of 2 ‑ Acylaminoimidazole Microsomal Prostaglandin E Synthase ‑ 1 InhibitorsInhibitors, Prostaglandin E Synthase; Schi, Matthew A; Antonysamy, Stephen; Bhattachar, Shobha N; Campanale, Kristina M; Chandrasekhar, Srinivasan; Condon, Bradley; Desai, Prashant V; Fisher, Matthew J; Groshong, Christopher; Harvey, Anita; Hickey, Michael J; Hughes,