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2016 JMC Volume 59 Issue 10 May (17).pdf.jpg2016Identi fi cation and Development of 2,3- Dihydropyrrolo[1,2 ‑ a ]quinazolin-5(1 H ) ‑ one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting ComplexSutherell, Charlotte L.
2016 JMC Volume 59 Issue 8 April (28).pdf.jpg2016Discovery of N ‑ (3-((1-Isonicotinoylpiperidin-4-yl)oxy)-4- methylphenyl)-3-(tri fl uoromethyl)benzamide (CHMFL-KIT-110) as a Selective, Potent, and Orally Available Type II c ‑ KIT Kinase Inhibitor for Gastrointestinal Stromal Tumors (GISTs)Wang, Qiang
2016 JMC Volume 59 Issue 19 October (7).pdf.jpg2016Metabolic Diseases Chemistry, ‡ Metabolic Diseases Biology, § PCO MAP, ∥ PCO Discovery Toxicology, and ⊥ PCO Bioanalytical Research, Bristol-Myers Squibb Research & Development, P.O. Box 4000, Princeton, New Jersey 08543, United StatesInhibitor, Mchr; Ahmad, Saleem; Washburn, William N; Hernandez, Andres S; Bisaha, Sharon; Ngu, Khehyong; Wang, Wei; Pelleymounter, Mary Ann; Longhi, Daniel; Flynn, Neil; Azzara, Anthony V; Rohrbach, Kenneth; Devenny, James; Rooney, Suzanne; Thomas, Michael; Glick, Susan
2016 JMC Volume 59 Issue 19 October (33).pdf.jpg2016Discovery of Orally E ffi cacious Phosphoinositide 3 ‑ Kinase δ Inhibitors with Improved Metabolic StabilityPatel, Leena; Chandrasekhar, Jayaraman; Evarts, Jerry; Forseth, Kristen; Haran, Aaron C; Ip, Carmen; Kashishian, Adam; Kim, Musong; Koditek, David; Koppenol, Sandy; Lad, Latesh; Lepist, Eve-irene; Mcgrath, Mary E; Perreault, Stephane; Puri, Kamal D; Villasen, Armando G
2016 JMC Volume 59 Issue 20 October (4).pdf.jpg2016Targeting the Translesion Synthesis Pathway for the Development of Anti-Cancer ChemotherapeuticsChemotherapeutics, Anti-cancer; Korzhnev, Dmitry M; Hadden, M Kyle
2016 JMC Volume 59 Issue 20 October (10).pdf.jpg2016Discovery of Selective Inhibitors Targeting Acetylcholinesterase 1 from Disease-Transmitting MosquitoesEngdahl, Cecilia; Linusson, Anna
2016 JMC Volume 59 Issue 21 November (22).pdf.jpg2016Chemical Inhibition of Human Thymidylate Kinase and Structural Insights into the Phosphate Binding Loop and Ligand-Induced DegradationChen, Yi-hsuan; Hsu, Hua-yi; Yeh, Ming-tyng; Chen, Chen-cheng; Huang, Chang-yu; Chung, Ying-hsuan; Chang, Zee-fen; Kuo, Wei-chen; Chan, Nei-li; Weng, Jui-hsia; Chung, Bon-chu; Chen, Yu-ju; Jian, Cheng-bang; Shen, Ching-chieh; Tai, Hwan-ching; Sheu, Sheh-yi; Fang, Jim-min
2016 JMC Volume 59 Issue 21 November (21).pdf.jpg2016Identi fi cation of a Potential Antimalarial Drug Candidate from a Series of 2 ‑ Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life CycleManach, Claire Le; Nchinda, Aloysius T; Paquet, Tanya; Gonza, Diego; Younis, Yassir; Han, Ze; Bashyam, Sridevi; Zabiulla, Mohammed; Taylor, Dale; Lawrence, Nina; White, Karen L; Charman, Susan A; Waterson, David; Witty, Michael J; Wittlin, Sergio; Ferrer, Santiago; Angul
2016 JMC Volume 59 Issue 21 November (28).pdf.jpg2016University of Michigan DRUG ANNOTATIONS EDITORS PERSPECTIVES EDITOR MANAGING EDITOR EDITOR EMERITUS EDITORIAL ADVISORY BOARDGeorg, Gunda; Wang, Shaomeng; Blagg, Brian S J; Bolognesi, Maria Laura; Conway, Stuart; Cushman, Mark; Glennon, Richard A; Haskell-luevano, Carrie; Holzgrabe, Ulrike; Garcia-echeverria, Carlos; Zablocki, Jeff; Greenlee, William J; Portoghese, Philip S; Aldrich, Courtn
2016 JMC Volume 59 Issue 21 November (18).pdf.jpg2016Active Site Mapping of an Aspartic Protease by Multiple Fragment Crystal Structures: Versatile Warheads To Address a Catalytic DyadRadeva, Nedyalka; Schiebel, Johannes; Wang, Xiaojie; Krimmer, Stefan G; Fu, Kan; Stieler, Martin; Ehrmann, Frederik R; Metz, Alexander; Rickmeyer, Thomas; Betz, Michael; Winquist, Johan; Park, Ah Young; Huschmann, Franziska U; Weiss, Manfred S; Mueller, Uwe; Heine, Andr
2016 JMC Volume 59 Issue 21 November (24).pdf.jpg2016Development of Allosteric Hydrazide-Containing Class I Histone Deacetylase Inhibitors for Use in Acute Myeloid LeukemiaMcclure, Jesse J; Zhang, Cheng; Inks, Elizabeth S; Peterson, Yuri K; Li, Jiaying; Chou, C James
2016 JMC Volume 59 Issue 21 November (2).pdf.jpg2016Therapeutic Potential of Foldamers : From Chemical Biology Tools To Drug Candidates ?Gopalakrishnan, Ranganath; Frolov, Andrey I; Knerr, Laurent; Drury, William J; Valeur, Eric
2016 JMC Volume 59 Issue 21 November (26).pdf.jpg2016In Vivo and In Vitro Optimization of Screening Antimalarial Hits toward Lead Molecules for Preclinical DevelopmentTsogoeva, Svetlana B
2016 JMC Volume 59 Issue 21 November (27).pdf.jpg2016Members contact:-
2016 JMC Volume 59 Issue 19 October (9).pdf.jpg2016Amending HIV Drugs: A Novel Small-Molecule Approach To Target Lupus Anti-DNA AntibodiesVanpatten, Sonya; Sun, Shan; He, Mingzhu; Cheng, Kai Fan; Altiti, Ahmad; Papatheodorou, Angelos; Kowal, Czeslawa; Jeganathan, Venkatesh; Crawford, James M; Bloom, Ona; Volpe, Bruce T; Grant, Christian; Meurice, Nathalie; Coleman, Thomas R; Diamond, Betty
2016 JMC Volume 59 Issue 19 October (5).pdf.jpg2016The Rational Design , Synthesis , and Antimicrobial Properties of Thiophene Derivatives That Inhibit Bacterial Histidine KinasesBoibessot, Thibaut; Zschiedrich, Christopher P; Lebeau, Alexandre; Be, David; Dunyach-re, Catherine; Benfodda, Zohra; Lavigne, Jean-philippe; Szurmant, Hendrik; Me, Patrick
2016 JMC Volume 59 Issue 20 October (6).pdf.jpg2016New Broad-Spectrum Antibacterial Amphiphilic Aminoglycosides Active against Resistant Bacteria: From Neamine Derivatives to Smaller Neosamine AnaloguesSautrey, Guillaume; S, Vinicius Barros R
2016 JMC Volume 59 Issue 21 November (15).pdf.jpg2016Identi fi cation of Tricyclic Agonists of Sphingosine-1-phosphate Receptor 1 (S1P 1 ) Employing Ligand-Based Drug DesignXiao, Hai-yun; Watterson, Scott H; Langevine, Charles M; Srivastava, Anurag S; Ko, Soo S; Zhang, Yanlei; Cherney, Robert J; Guo, Wei-wei; Gilmore, John L; Sheppeck, James E; Wu, Dauh-rurng; Li, Peng; Ramasamy, Duraisamy; Arunachalam, Piramanayagam; Mathur, Arvind; Taylo
2016 JMC Volume 59 Issue 19 October (15).pdf.jpg2016Design, Synthesis, and Biological Evaluation of First-in-Class Dual Acting Histone Deacetylases (HDACs) and Phosphodiesterase 5 (PDE5) Inhibitors for the Treatment of Alzheimer ’ s DiseaseCuadrado-tejedor, Mar; Miguel, Irene De; Garc, Carolina; Ugarte, Ana; Mendoza, Ander Estella-hermoso De; Sa, Elena; Espelosin, Maria; Ursua, Susana; Haizhong, Tan; Wei, Wu; Musheng, Xu; Garcia-osta, Ana; Oyarzabal, Julen
2016 JMC Volume 59 Issue 19 October (27).pdf.jpg2016Identi fi cation of a New Class of Selective Excitatory Amino Acid Transporter Subtype 1 (EAAT1) Inhibitors Followed by a Structure − Activity Relationship StudyHansen, Stinne W; Erichsen, Mette N; Fu, Bingru; Bjørn-yoshimoto, Walden E; Abrahamsen, Bjarke; Hansen, Jacob C; Jensen, Anders A; Bunch, Lennart