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2016 JMC Volume 59 Issue 10 May (17).pdf.jpg2016Identi fi cation and Development of 2,3- Dihydropyrrolo[1,2 ‑ a ]quinazolin-5(1 H ) ‑ one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting ComplexSutherell, Charlotte L.
2016 JMC Volume 59 Issue 8 April (28).pdf.jpg2016Discovery of N ‑ (3-((1-Isonicotinoylpiperidin-4-yl)oxy)-4- methylphenyl)-3-(tri fl uoromethyl)benzamide (CHMFL-KIT-110) as a Selective, Potent, and Orally Available Type II c ‑ KIT Kinase Inhibitor for Gastrointestinal Stromal Tumors (GISTs)Wang, Qiang
2016 JMC Volume 59 Issue 6 March (16).pdf.jpg2016Andrew M. Thompson, * , † Patrick D. O ’ Connor, † Adrian Blaser, † Vanessa Yardley, ‡ Louis Maes, § Suman Gupta, ∥ Delphine Launay, ⊥ Denis Martin, ⊥ Scott G. Franzblau, # Baojie Wan, # Yuehong Wang, # Zhenkun Ma, ¶ and William A. Denny † †Thompson, Andrew M; Connor, Patrick D O; Blaser, Adrian; Yardley, Vanessa; Maes, Louis; Gupta, Suman; Launay, Delphine; Martin, Denis; Franzblau, Scott G; Wan, Baojie; Wang, Yuehong; Ma, Zhenkun; Denny, William A
2016 JMC Volume 59 Issue 5 March (25).pdf.jpg2016MutantsCheng, Hengmiao; Nair, Sajiv K; Murray, Brion W; Almaden, Chau; Bailey, Simon; Baxi, Sangita; Behenna, Doug; Cho-schultz, Sujin; Dalvie, Deepak; Dinh, Dac M; Edwards, Martin P; Feng, Jun Li; Ferre, Rose Ann; Gajiwala, Ketan S; Hemkens, Michelle D; Jackson-fisher, Amy; Ja
2016 JMC Volume 59 Issue 7 April (32).pdf.jpg2016Identi fi cation of a Human Toll-Like Receptor (TLR) 8 ‑ Speci fi c Agonist and a Functional Pan-TLR Inhibitor in 2 ‑ AminoimidazolesBeesu, Mallesh; Caruso, Giuseppe; Salyer, Alex C D; Shukla, Nijunj M; Khetani, Karishma K; Smith, Luke J; Fox, Lauren M; Tanji, Hiromi; Ohto, Umeharu; Shimizu, Toshiyuki; David, Sunil A
2016 JMC Volume 59 Issue 6 March (25).pdf.jpg2016Hydroxypyrimidine-2,4-diones as Selective Active Site Inhibitors of HIV Reverse Transcriptase-Associated RNase H: Design, Synthesis, and Biochemical EvaluationsTang, Jing; Liu, Feng; Nagy, Eva; Miller, Lena; Kirby, Karen A; Wilson, Daniel J; Wu, Bulan; Sara, Stefan G; Parniak, Michael A; Wang, Zhengqiang
2016 JMC Volume 59 Issue 3 February (34).pdf.jpg2016Potent μ ‑ Opioid Receptor Agonists from Cyclic Peptides Tyr ‑ c [Li, Yangmei; Cazares, Margret; Wu, Jinhua; Houghten, Richard A; Toll, Laurence; Dooley, Colette; Pines, Torrey; Studies, Molecular; Parkway, S W Village; Lucie, Port St; States, United
2016 JMC Volume 59 Issue 3 February (10).pdf.jpg2016Indole Based Weapons to Fight Antibiotic Resistance: A Structure − Activity Relationship StudyLepri, Susan; Buonerba, Federica; Goracci, Laura; Velilla, Irene; Ruzziconi, Renzo; Schindler, Bryan D; Seo, Susan M; Kaatz, Glenn W; Cruciani, Gabriele
2016 JMC Volume 59 Issue 3 February (33).pdf.jpg2016Novel Water-Soluble Amphotericin B ‑ PEG Conjugates with Low Toxicity and Potent in Vivo E ffi cacyHalperin, Assaf; Shadkchan, Yana; Pisarevsky, Evgeni; Szpilman, Alex M; Sandovsky, Hani; Osherov, Nir; Benhar, Itai
2016 JMC Volume 59 Issue 2 January (14).pdf.jpg2016In Vitro Evaluation of the Interaction of Dextrin − Colistin Conjugates with Bacterial LipopolysaccharideRoberts, Jessica L; Cattoz, Beatrice; Schweins, Ralf; Beck, Konrad; Thomas, David W; Gri, Peter C; Ferguson, Elaine L
2016 JMC Volume 59 Issue 1 January (22).pdf.jpg2016Nonpeptidic Amphiphilic Xanthone Derivatives: Structure − Activity Relationship and Membrane-Targeting PropertiesKoh, Wee Luan; Li, Jianguo; Lakshminarayanan, Rajamani; Verma, Chandra
2016 JMC Volume 59 Issue 4 February (5).pdf.jpg2016Structure-Guided Design of IACS-9571, a Selective High-A ffi nity Dual TRIM24-BRPF1 Bromodomain InhibitorPalmer, Wylie S; Poncet-montange, Guillaume; Liu, Gang; Petrocchi, Alessia; Reyna, Naphtali; Subramanian, Govindan; Thero, Jay; Yau, Anne; Kost-alimova, Maria; Bardenhagen, Jennifer P; Leo, Elisabetta; Shepard, Hannah E; Tieu, Trang N; Shi, Xi; Zhan, Yanai; Zhao, Shupin
2016 JMC Volume 59 Issue 6 March (8).pdf.jpg2016Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of SchistosomiasisHeimburg, Tino; Chakrabarti, Alokta; Lancelot, Julien; Marek, Martin; Melesina, Jelena; Hauser, Alexander-thomas; Shaik, Tajith B; Duclaud, Sylvie; Robaa, Dina; Erdmann, Frank; Schmidt, Matthias; Romier, Christophe; Pierce, Raymond J; Jung, Manfred; Sippl, Wolfgang
2016 JMC Volume 59 Issue 6 March (3).pdf.jpg2016Conopeptide-Derived κ ‑ Opioid Agonists (Conorphins): Potent, Selective, and Metabolic Stable Dynorphin A Mimetics with Antinociceptive PropertiesBrust, Andreas; Croker, Daniel E; Colless, Barbara; Ragnarsson, Lotten; Andersson, Åsa; Jain, Kapil; Garcia-caraballo, Sonia; Castro, Joel; Brierley, Stuart M; Alewood, Paul F; Lewis, Richard J
2016 JMC Volume 59 Issue 4 February (26).pdf.jpg2016Structure-Based Identi fi cation of Inhibitory Fragments Targeting the p300/CBP-Associated Factor BromodomainBromodomain, Cbp-associated Factor; Chaikuad, Apirat; Brennan, Paul E; Temperini, Claudia; Fedorov, Oleg; Hollander, Johan; Nachane, Ruta; Abell, Chris; Mu, Susanne; Siegal, Gregg; Knapp, Stefan
2016 JMC Volume 59 Issue 2 January (19).pdf.jpg2016Subhas S. Karki, † , # Umashankar Das, * , † Naoki Umemura, ‡ Hiroshi Sakagami, ‡ Shoko Iwamoto, ‡ Masami Kawase, § Jan Balzarini, ∥ Erik De Clercq, ∥ Stephen G. Dimmock, ⊥ and Jonathan R. Dimmock * , † †Karki, Subhas S; Das, Umashankar; Umemura, Naoki; Sakagami, Hiroshi; Iwamoto, Shoko; Kawase, Masami; Balzarini, Jan; Clercq, Erik De; Dimmock, Stephen G; Dimmock, Jonathan R
2016 JMC Volume 59 Issue 1 January (30).pdf.jpg2016Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Di ff erent Binding Modes at AMPA ReceptorsSzymanska, Ewa; Frydenvang, Karla; Pickering, Darryl S; Krintel, Christian; Nielsen, Birgitte; Kooshki, Ayesheh; Zachariassen, Linda G; Olsen, Lars; Kastrup, Jette S; Johansen, Tommy N
2016 JMC Volume 59 Issue 3 February (1).pdf.jpg2016Correction to Phenyl Ether- and Aniline-Containing 2 ‑ Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide SynthaseCinelli, Maris A; Li, Huiying; Pensa, Anthony V; Kang, Soosung; Roman, Linda J; Marta, Pavel
2016 JMC Volume 59 Issue 2 January (18).pdf.jpg2016Structure-Based Discovery of Novel and Selective 5 ‑ Hydroxytryptamine 2B Receptor Antagonists for the Treatment of Irritable Bowel SyndromeZhou, Yu; Lin, Xingyu; Huang, Xi-ping; Wu, Kaichun; Huang, Niu
2016 JMC Volume 59 Issue 7 April (1).pdf.jpg2016Anti-HIV Drug Discovery and Development : Current Innovations and Future TrendsZhan, Peng; Pannecouque, Christophe; Clercq, Erik De; Liu, Xinyong