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PreviewIssue DateTitleContributor(s)
2016 JMC Volume 59 Issue 10 May (17).pdf.jpg2016Identi fi cation and Development of 2,3- Dihydropyrrolo[1,2 ‑ a ]quinazolin-5(1 H ) ‑ one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting ComplexSutherell, Charlotte L.
2016 JMC Volume 59 Issue 8 April (28).pdf.jpg2016Discovery of N ‑ (3-((1-Isonicotinoylpiperidin-4-yl)oxy)-4- methylphenyl)-3-(tri fl uoromethyl)benzamide (CHMFL-KIT-110) as a Selective, Potent, and Orally Available Type II c ‑ KIT Kinase Inhibitor for Gastrointestinal Stromal Tumors (GISTs)Wang, Qiang
2016 JMC Volume 59 Issue 11 June (5).pdf.jpg2016Cancer Research UK Cancer Therapeutics Unit and ‡ Division of Radiotherapy and Imaging, The Institute of Cancer Research, London SM2 5NG, U.K. § Sareum Ltd., Cambridge CB22 3FX, U.K.Osborne, James D; Matthews, Thomas P; Mchardy, Tatiana; Proisy, Nicolas; Cheung, Kwai-ming J; Lainchbury, Michael; Brown, Nathan; Walton, Michael I; Eve, Paul D; Boxall, Katherine J; Hayes, Angela; Henley, Alan T; Valenti, Melanie R; Brandon, Alexis K De Haven; Box, Gary; Jamin, Yann; Robinson, Simon P; Westwood, Isaac M; Montfort, Rob L M Van; Leonard, Philip M; Lamers, Marieke B A C; Reader, John C; Aherne, G Wynne; Raynaud, Florence I; Eccles, Suzanne A; Garrett, Michelle D; Collins, Ian
2016 JMC Volume 59 Issue 10 May (36).pdf.jpg2016Discovery of Benzofuran Derivatives that Collaborate with Insulin- Like Growth Factor 1 (IGF-1) to Promote NeuroprotectionWakabayashi, Takeshi; Tokunaga, Norihito; Tokumaru, Kazuyuki; Ohra, Taiichi; Koyama, Nobuyuki; Hayashi, Satoru; Yamada, Ryuji; Shirasaki, Mikio; Inui, Yoshitaka; Tsukamoto, Tetsuya
2016 JMC Volume 59 Issue 10 May (19).pdf.jpg2016Design, Synthesis, and Structure − Activity Relationship Study of Novel Indole-2-carboxamide Derivatives as Anti-in fl ammatory Agents for the Treatment of SepsisLiu, Zhiguo; Tang, Longguang; Zhu, Heping; Xu, Tingting; Qiu, Chenyu; Zheng, Suqing; Gu, Yugui; Feng, Jianpeng; Zhang, Yali; Liang, Guang
2016 JMC Volume 59 Issue 12 June (22).pdf.jpg2016Benzyl [ 11 C]Hippurate as an Agent for Measuring the Activities of Organic Anion Transporter 3 in the Brain and Multidrug Resistance- Associated Protein 4 in the Heart of MiceKikuchi, Tatsuya; Okamura, Toshimitsu; Okada, Maki; Ogawa, Masanao; Suzuki, Chie
2016 JMC Volume 59 Issue 10 May (38).pdf.jpg2016Discovery of a Potent, Selective, Orally Bioavailable, and E ffi cacious Novel 2 ‑ (Pyrazol-4-ylamino)-pyrimidine Inhibitor of the Insulin-like Growth Factor ‑ 1 Receptor (IGF-1R)Degorce, L; Boyd, Scott; Curwen, Jon O; Ducray, Richard; Halsall, Christopher T; Jones, D; Lach, Franck; Lenz, Eva M; Pass, Martin; Pass, Sarah; Trigwell, Catherine
2016 JMC Volume 59 Issue 10 May (47).pdf.jpg2016Effects of N ‑ Substitutions on the Tetrahydroquinoline (THQ) Core of Mixed-E ffi cacy μ ‑ Opioid Receptor (MOR)/ δ -Opioid Receptor (DOR) LigandsHarland, Aubrie A; Bender, Aaron M; Griggs, Nicholas W; Gao, Chao; Anand, Jessica P; Pogozheva, Irina D; Traynor, John R; Jutkiewicz, Emily M; Mosberg, Henry I
2016 JMC Volume 59 Issue 8 April (10).pdf.jpg2016Design, Synthesis, and Evaluation of Fluorinated Radioligands for Myelin ImagingTiwari, Anand Dev; Wu, Chunying; Zhu, Junqing; Zhang, Sheng; Zhu, Jinle; Wang, William R; Zhang, Jinming; Tatsuoka, Curtis; Matthews, Paul M; Miller, Robert H; Wang, Yanming
2016 JMC Volume 59 Issue 9 May (25).pdf.jpg2016Big Data from Pharmaceutical Patents: A Computational Analysis of Medicinal Chemists ’ Bread and ButterSchneider, Nadine; Lowe, Daniel M; Sayle, Roger A; Tarselli, Michael A; Landrum, Gregory A
2016 JMC Volume 59 Issue 8 April (27).pdf.jpg2016Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA- Dependent RNA Polymerase from a Fragment Hit Using Structure- Based Drug DesignYokokawa, Fumiaki; Nilar, Shahul; Noble, Christian G; Lim, Siew Pheng; Rao, Ranga; Tania, Stefani; Wang, Gang; Lee, Gladys; Hunziker, Ju; Karuna, Ratna; Manjunatha, Ujjini; Shi, Pei-yong; Smith, Paul W
2016 JMC Volume 59 Issue 12 June (13).pdf.jpg2016Design, Synthesis, and Preclinical Evaluation of 4 ‑ Substituted-5- methyl-furo[2,3 ‑ d ]pyrimidines as Microtubule Targeting Agents That Are E ff ective against Multidrug Resistant Cancer CellsKumar, Ravi; Devambatla, Vyas; Namjoshi, Ojas A; Choudhary, Shruti; Hamel, Ernest; Sha, Corena V; Rohena, Cristina C; Mooberry, Susan L; Gangjee, Aleem
2016 JMC Volume 59 Issue 10 May (33).pdf.jpg2016Discovery and Structure − Activity Relationships of the Neoseptins: A New Class of Toll-like Receptor ‑ 4 (TLR4) AgonistsMorin, Matthew D; Wang, Ying; Jones, Brian T; Su, Lijing; Surakattula, Murali M R P; Berger, Michael; Huang, Hua; Beutler, Elliot K; Zhang, Hong; Beutler, Bruce; Boger, Dale L
2016 JMC Volume 59 Issue 8 April (7).pdf.jpg2016Discovery of an Orally Active and Liver-Targeted Prodrug of 5 ‑ Fluoro-2 ′ -Deoxyuridine for the Treatment of Hepatocellular CarcinomaPeng, Youmei; Yu, Wenquan; Li, Ertong; Kang, Jinfeng; Wang, Yafeng; Yang, Qinghua; Liu, Bingjie; Zhang, Jingmin; Li, Longyu; Wu, Jie; Jiang, Jinhua; Wang, Qingduan; Chang, Junbiao
2016 JMC Volume 59 Issue 12 June (25).pdf.jpg2016Discovery of New Chemical Entities for Old Targets: Insights on the Lead Optimization of Chromone-Based Monoamine Oxidase B (MAO- B) InhibitorsReis, Joana; Cagide, Fernando; Chavarria, Daniel; Silva, Tiago; Fernandes, Carlos; Gaspar, Alexandra; Uriarte, Eugenio; Remia, Fernando; Alcaro, Stefano; Ortuso, Francesco
2016 JMC Volume 59 Issue 10 May (28).pdf.jpg2016Discovery of Benzocycloalkane Derivatives E ffi ciently Blocking Bacterial Virulence for the Treatment of Methicillin-Resistant S. aureus (MRSA) Infections by Targeting Diapophytoene Desaturase (CrtN)Lu, Yanli; Zhang, Lingling; Zhu, Jin; Lan, Lefu; Li, Jian
2016 JMC Volume 59 Issue 10 May (7).pdf.jpg2016Development of Small Molecules that Speci fi cally Inhibit the D ‑ loop Activity of RAD51Lv, Wei; Budke, Brian; Pawlowski, Michal; Connell, Philip P; Kozikowski, Alan P
2016 JMC Volume 59 Issue 10 May (40).pdf.jpg2016Design, Synthesis, and Biological Evaluation of Potential Prodrugs Related to the Experimental Anticancer Agent Indotecan (LMP400)Cushman, Mark
2016 JMC Volume 59 Issue 9 May (19).pdf.jpg2016Docking Screens for Novel Ligands Conferring New BiologyIrwin, John J; Shoichet, Brian K
2016 JMC Volume 59 Issue 10 May (49).pdf.jpg2016Isatin Derived Spirocyclic Analogues with α ‑ Methylene- γ - butyrolactone as Anticancer Agents: A Structure − Activity Relationship StudyRana, Sandeep; Blowers, Elizabeth C; Tebbe, Calvin; Contreras, Jacob I; Radhakrishnan, Prakash; Kizhake, Smitha; Zhou, Tian; Rajule, Rajkumar N; Arnst, Jamie L; Munkarah, Adnan R